”Hidden Resistance”
نویسندگان
چکیده
منابع مشابه
Modelling proteins’ hidden conformations to predict antibiotic resistance
TEM β-lactamase confers bacteria with resistance to many antibiotics and rapidly evolves activity against new drugs. However, functional changes are not easily explained by differences in crystal structures. We employ Markov state models to identify hidden conformations and explore their role in determining TEM's specificity. We integrate these models with existing drug-design tools to create a...
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ژورنال
عنوان ژورنال: Spaces and Ideas
سال: 2017
ISSN: 1419-0222
DOI: 10.14232/belv.2017.4.2